• Preheat the oven to 350°F. Prepare a 9 in. x 5 in. x 3 in. loaf pan by lining with parchment paper or greasing it well.
• In a large mixing bowl, or the bowl of a stand mixer, cream butter and sugar until light and fluffy.  Add eggs, one at a time, incorporating well after each addition. 
• Add yogurt, orange juice, orange zest, and vanilla extract.
• Whisk together flour, baking powder, baking soda, and salt in a medium bowl. Slowly add the dry ingredients to the wet ingredients, and mix until just incorporated.
• Pour into prepared loaf pan. Bake for 55-65 minutes or until a toothpick inserted into the center comes out clean. (If top is browning too quickly, cover loosely with a piece of foil and continue to bake.)
• Remove from oven when done and cool slightly.

Make Glaze

• Meanwhile, combine confectioners' sugar and orange juice in a small bowl (add a bit at a time until desired consistency is reached).
• Drizzle over bread while still slightly warm.
• Allow bread to cool for at least 30-40 minutes before removing from pan or cutting to avoid a crumbly mess. I know it's hard because it smells so darn good, but trust me, you'll be glad you did.